Cut the block of cheese into 8 cubes approximately 1"x1". Cut the pepperoni into quarters, if desired.
For each biscuit, place a cube of cheese and some pepperoni in the center. Using your fingers, pull the edges of the biscuit out and pinch them together firmly to form a ball.
Place seam-side down on a tray and bake for approx. 15 minutes or until golden brown.